{"id":234,"date":"2019-02-16T17:30:17","date_gmt":"2019-02-16T17:30:17","guid":{"rendered":"https:\/\/wordpress.ape\/?page_id=234"},"modified":"2023-03-30T16:01:56","modified_gmt":"2023-03-30T14:01:56","slug":"human-brain-project","status":"publish","type":"page","link":"https:\/\/apegate.roma1.infn.it\/?page_id=234","title":{"rendered":"Human Brain Project"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"234\" class=\"elementor elementor-234\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ed5de60 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ed5de60\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-70f4dc6\" data-id=\"70f4dc6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fa0c7da elementor-widget elementor-widget-heading\" data-id=\"fa0c7da\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Human Brain Project (HBP)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3a68af4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3a68af4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-b00e884\" data-id=\"b00e884\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b3559e2 elementor-widget elementor-widget-image\" data-id=\"b3559e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.humanbrainproject.eu\" target=\"_blank\">\n\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/apegate.roma1.infn.it\/wp-content\/uploads\/elementor\/thumbs\/LogoHBP-o3ut932f3xk9zpj53c78p6hzw35hd78rdk7iphblng.jpg\" title=\"LogoHBP\" alt=\"LogoHBP\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 150px; --smush-placeholder-aspect-ratio: 150\/150;\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3073085\" data-id=\"3073085\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-841b7a3 elementor-widget elementor-widget-text-editor\" data-id=\"841b7a3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The Human Brain Project is a European-funded research initiative involving more than 100 institutions all over the continent.\u00a0<span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">The goal of the project is to unveil the secrets of the human brain and uncover the mechanisms responsible for cognitive processes, learning and consciousness.\u00a0<\/span><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">The key-word for HBP is\u00a0<\/span><span style=\"font-size: 15px; font-style: normal; font-weight: bold;\">multi-disciplinarity<\/span><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">: HBP is not only a fruitful ground for pioneering research in the field of neuroscience, but also a successful experiment of collaboration between several different scientists, bridging together medical doctors, biologists, physicists,\u00a0<\/span><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">computer scientists,\u00a0<\/span><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">engineers and philosophers, and linking experimental data with theoretical models and high-performance computer simulations.\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-f3bf944 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f3bf944\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-f3f0b40\" data-id=\"f3f0b40\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8bd458d elementor-widget elementor-widget-text-editor\" data-id=\"8bd458d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">HBP started in 2013, with the so-called\u00a0<\/span><em style=\"font-size: 15px; font-weight: 400;\">ramp-up<\/em><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">\u00a0phase, during which the backbone and the main scientific targets of the project have been defined. In this starting phase, calls have been opened to the scientific community\u00a0<\/span><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">in order to extend the objectives of research and to address specific goals.\u00a0 A<\/span><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">\u00a0dedicated scientific board selected the projects that won the competition\u00a0<\/span><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">among the several applicants, forming\u00a0<\/span><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">what is now called the\u00a0<span style=\"font-size: 15px; font-weight: bold;\">Systems and Cognitive Neuroscience\u00a0<\/span><\/span><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">Sub-Project\u00a0<\/span><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">(SP3)<\/span><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">. One of the <a href=\"https:\/\/apegate.roma1.infn.it\/?page_id=835#HBP\" target=\"_blank\" rel=\"noopener\">4 winner projects<\/a> was\u00a0<span style=\"font-size: 15px; font-weight: bold;\">WaveScalES<\/span>, led by\u00a0<\/span><a style=\"font-size: 15px; font-style: normal; font-weight: 400; background-color: #ffffff;\" href=\"mailto:pier.paolucci@roma1.infn.it\">Pier Stanislao Paolucci<\/a><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">.\u00a0With it, APE Lab and INFN entered the HBP project since its first Scientific Grant Agreement phase (SGA1, 2016-2018), guiding an\u00a0<\/span><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">international collaboration aimed at investigating the role of the different expressions of electrophysiological activity of the cortex during deep sleep. Activities went on during\u00a0<\/span><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">the SGA2 (2018-2020), followed by SGA3 in 2020 and came to a conclusion in 2023. In these years, we have consolidated our position in the field, gaining experience and extending our network and lines of actions. O<\/span><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">ur past and present research interests and efforts are focused on several items (<a href=\"https:\/\/apegate.roma1.infn.it\/?page_id=335\" target=\"_blank\" rel=\"noopener\">theses available<\/a>):<\/span><\/p><ul style=\"font-size: 15px; font-style: normal;\"><li style=\"font-weight: 400; font-size: 15px;\"><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">hardware and software co-design for <strong>distributed spiking neural network simulations<\/strong> on parallel computing architectures (DPSNN)<\/span><\/li><li style=\"font-weight: 400; font-size: 15px;\">hardware and software co-design for <strong>neuromorphic computing<\/strong> systems (focus on network, latency, scalability)<\/li><li style=\"font-weight: 400; font-size: 15px;\"><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\"><strong>data analysis<\/strong> (electrophysiological and imaging data from rodents and monkeys)<\/span><\/li><li style=\"font-weight: 400; font-size: 15px;\"><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\"><strong>data-driven inference-based mean-field models\u00a0<\/strong><\/span><\/li><li style=\"font-size: 15px;\"><span style=\"font-size: 15px; font-style: normal;\"><b>thalamo-cortical spiking models<\/b><\/span><span style=\"font-weight: 400; font-size: 15px; font-style: normal;\"> of <\/span><span style=\"font-size: 15px; font-style: normal;\"><b>sleep and wakefulness<\/b><\/span><span style=\"font-weight: 400; font-size: 15px; font-style: normal;\">\u00a0<\/span><\/li><li style=\"font-weight: 400; font-size: 15px;\"><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\"><strong>software tools<\/strong> for the HBP-EBRAINS infrastructure platforms<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1ce728d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1ce728d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-786c729\" data-id=\"786c729\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-50eb586 elementor-tabs-view-horizontal elementor-widget elementor-widget-tabs\" data-id=\"50eb586\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-tabs\">\n\t\t\t<div class=\"elementor-tabs-wrapper\" role=\"tablist\" >\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-8481\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-8481\" aria-expanded=\"false\">ThaCo<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-8482\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-8482\" aria-expanded=\"false\">Cobrawap<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-8483\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-8483\" aria-expanded=\"false\">WaveScalES<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-8484\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-8484\" aria-expanded=\"false\">Inference methods<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-8485\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"5\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-8485\" aria-expanded=\"false\">DPSNN<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-8486\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"6\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-8486\" aria-expanded=\"false\">SWAP<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-8487\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"7\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-8487\" aria-expanded=\"false\">Collaborators & Partners<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"elementor-tabs-content-wrapper\" role=\"tablist\" aria-orientation=\"vertical\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-8481\" aria-expanded=\"false\">ThaCo<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-8481\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-8481\" tabindex=\"0\" hidden=\"false\"><p>ThaCo is a thalamo-cortical spiking model able to integrate some biological features of sleep states and wakefulness and perform classification tasks exploiting bio-inspired mechanisms for learning and memory formation.<\/p><p><a href=\"https:\/\/journals.plos.org\/ploscompbiol\/article\/authors?id=10.1371\/journal.pcbi.1009045\">Learn more&#8230;<\/a><\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-8482\" aria-expanded=\"false\">Cobrawap<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-8482\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-8482\" tabindex=\"0\" hidden=\"hidden\"><p>Cobrawap is a <strong>Collaborative Brain Wave Analysis Pipeline<\/strong> developed by APE Lab together with several partners in the framework of HBP-EBRAINS.<\/p><p>Cobrawap collected the inheritance of the SWAP project, enhancing modularity and generalizability of the algorithms.<\/p><p>Further details on <a href=\"https:\/\/arxiv.org\/abs\/2211.08527\">arXiv:2211.08527<\/a> [q-bio.NC] and <a href=\"https:\/\/github.com\/INM-6\/cobrawap\">GitHub<\/a><\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-8483\" aria-expanded=\"false\">WaveScalES<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-8483\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-8483\" tabindex=\"0\" hidden=\"hidden\"><div><div style=\"padding: 0cm; margin-left: 54pt; margin-right: 0cm; border: 1pt none black;\">\u00a0<\/div><\/div><div>The human brain needs sleep, and <strong>chronic sleep deprivation reduces cognitive performances<\/strong>. Cortical slow wave activity (SWA) characterises deep sleep, anaesthesia <strong>and<\/strong> coma, but a complete understanding of the underlying mechanisms and of the <strong>emergence towards wakefulness and consciousness<\/strong> is still lacking. The WaveScalES project aims at uncovering the <b>link between Sleep and Learning<\/b>, bridging theoretical models, experimental activity and dedicated simulations.\u00a0The name has been chosen to recall the different aspects of the project:<\/div><ul><li style=\"font-size: 15px; font-style: normal;\"><span style=\"font-size: 15px;\"><b>slow waves<\/b>, as the distinctive signature of the brain activity which manifests during deep sleep and constitutes our main target of research;<\/span><\/li><li style=\"font-size: 15px; font-style: normal;\"><span style=\"font-size: 15px;\"><b>multi-scales<\/b>, to underline our aim of addressing the process at the different scales of investigation (microscale \u2014 the cells; mesoscale \u2014 cortical columns and cortical areas;\u00a0 macroscale \u2014 the bedside);<\/span><\/li><li>E for <b style=\"font-size: 15px; font-style: normal;\">Experiments<\/b>, S for <b style=\"font-size: 15px; font-style: normal;\">Simulations<\/b>, since experimental data and computer-based realizations of theoretical models are the tools we leverage for our research purposes.<\/li><\/ul><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-8484\" aria-expanded=\"false\">Inference methods<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-8484\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-8484\" tabindex=\"0\" hidden=\"hidden\"><p><a href=\"https:\/\/www.nature.com\/articles\/s42003-023-04580-0\">Simulations approaching data<\/a> is the goal we aim at achieving when devising mean-field models of cortical activity. Inference methods are adopted, matched with validation techniques that allow to iteratively compare experimental target data and the outcomes of numerical simulations in order to refine model parameters and obtain cortical dynamics that contains the main features observed in the experiments reducing the amount of stereotyped signatures that generative models may contain.<\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"5\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-8485\" aria-expanded=\"false\">DPSNN<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-8485\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-8485\" tabindex=\"0\" hidden=\"hidden\"><figure id=\"attachment_881\" aria-describedby=\"caption-attachment-881\" style=\"width: 300px\" class=\"wp-caption alignright\"><img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/apegate.roma1.infn.it\/wp-content\/uploads\/2019\/02\/DPSNN-Sim-300x225.jpeg\" alt=\"\" width=\"300\" height=\"225\" \/><figcaption id=\"caption-attachment-881\" class=\"wp-caption-text\"><span style=\"font-size: 13px; font-style: normal; font-weight: 400;\">Slow Wave Simulation on DPSNN at a given timestamp, with 96&#215;96 cortical columns, 1250 neurons per column, ~1500 equivalent synapses per neuron, for a total of 11.5M neurons and 17.5G synapses<\/span><\/figcaption><\/figure><p>DPSNN (<span style=\"font-size: 15px; font-weight: 400;\"><strong>Distributed Plastic Spiking Neural Network<\/strong> simulation engine<\/span><span style=\"font-size: 15px;\">) is the brain simulator developed by the APE Lab. It represents the first outcome that APE Lab delivered in the field of spiking simulation.<\/span><\/p><p><span style=\"font-size: 15px;\">Originally devised as a mini-application for testing the parallel computing architectures in the framework of <\/span><a style=\"font-size: 15px; background-color: #ffffff;\" href=\"https:\/\/apegate.roma1.infn.it\/?page_id=656\">ExaNeSt<\/a><span style=\"font-size: 15px;\">, its performance has been improved to include short- and long-range connectivity and synaptic plasticity, and to be extended towards multi-areal cortical activity. It can accommodate different theoretical models for the neuron and the network.<\/span><\/p><p><span style=\"font-size: 15px;\">Its strengths are <\/span><strong style=\"font-size: 15px;\">speed<\/strong><span style=\"font-size: 15px;\">, <\/span><strong style=\"font-size: 15px;\">reliability<\/strong><span style=\"font-size: 15px;\"> and <\/span><strong style=\"font-size: 15px;\">scalability<\/strong><span style=\"font-size: 15px;\">, and its results are comparable to those obtained with <\/span><a style=\"font-size: 15px; background-color: #ffffff;\" href=\"http:\/\/www.nest-simulator.org\/\">NEST<\/a><span style=\"font-size: 15px;\">.<\/span><\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"6\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-8486\" aria-expanded=\"false\">SWAP<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-8486\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-8486\" tabindex=\"0\" hidden=\"hidden\"><figure id=\"attachment_871\" aria-describedby=\"caption-attachment-871\" style=\"width: 400px\" class=\"wp-caption alignright\"><img decoding=\"async\" class=\"wp-image-871 lazyload\" style=\"--smush-placeholder-width: 400px; --smush-placeholder-aspect-ratio: 400\/327;font-style: inherit;\" data-src=\"https:\/\/apegate.roma1.infn.it\/wp-content\/uploads\/2019\/02\/SOperiod-withMargins-e1551258389927.jpeg\" alt=\"\" width=\"400\" height=\"327\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" \/><figcaption id=\"caption-attachment-871\" class=\"wp-caption-text\"><span style=\"font-size: 13px; font-style: normal; font-weight: 400;\">The period of the slow oscillations depends on the position on the cerebral cortex; the fronto-lateral regions manifest a larger excitability (data from anesthetized mouse).<\/span><\/figcaption><\/figure><p>SWAP is <strong>Slow Waves Analysis Pipeline<\/strong>, a\u00a0<span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">robust analysis procedure capable to extract, plot and statistically evaluate the features of slow oscillations and slow waves, offering a set of software tools and methods that allow going from raw-data to statistical assessment of results. It represents the first outcome that APE Lab delivered in the filed of brain data analysis.<\/span><\/p><p><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">SWAP has been largely employed in the analysis of experimental data. Currently, efforts have been directed to the improvement of the pipeline towards <strong>robustness and flexibility<\/strong>, aimed at extending the range of applicability (including the outcome of simulations) and at integrating it into the HBP<\/span><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">\u00a0platforms.<\/span><\/p><p><span style=\"font-size: 16px;\">Among recent results obtained with SWAP, we have evaluated the <\/span><strong style=\"font-size: 16px;\">differentiation of cortical areas<\/strong><span style=\"font-size: 16px;\">, and we highlight the presence of <\/span><strong style=\"font-size: 16px;\">gradients of excitability<\/strong><span style=\"font-size: 16px;\">, in particular along a direction from fronto-lateral towards occipito-medial regions. This outcome can offer a new perspective on the <\/span><strong style=\"font-size: 16px;\">classification of brain states<\/strong><span style=\"font-size: 16px;\"> and new input for <\/span><strong style=\"font-size: 16px;\">theoretical models<\/strong><span style=\"font-size: 16px;\"> and <\/span><strong style=\"font-size: 16px;\">data-driven simulations.<\/strong><strong style=\"font-size: 15px;\">\u00a0<\/strong><\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"7\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-8487\" aria-expanded=\"false\">Collaborators & Partners<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-8487\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"7\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-8487\" tabindex=\"0\" hidden=\"hidden\"><div><b><u>WaveScalES partners<\/u><\/b><\/div><ul style=\"font-size: 15px; font-style: normal; font-weight: 400;\"><li style=\"font-size: 15px; font-style: normal; font-weight: 400;\"><a style=\"font-size: 15px;\" href=\"https:\/\/www.iss.it\/\" target=\"_blank\" rel=\"noopener\">Istituto Superiore di Sanit\u00e0<\/a>\u00a0(ISS) (M. Mattia), Rome, Italy.<\/li><li style=\"font-size: 15px; font-style: normal; font-weight: 400;\">University of Milan,\u00a0<a style=\"font-size: 15px;\" href=\"http:\/\/www.dibic.unimi.it\/ecm\/home\" target=\"_blank\" rel=\"noopener\">Department of Clinical Sciences &#8220;L. Sacco&#8221;\u00a0<\/a>(M.Massimini), Milan, Italy.<\/li><li style=\"font-size: 15px; font-style: normal; font-weight: 400;\"><span style=\"font-size: 15px;\">Institut\u00a0<\/span><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">d&#8217;Investigacions Biom\u00e8diques August Pi i Sunyer (I<\/span><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">DIBAPS),\u00a0<\/span><a style=\"font-size: 15px; font-style: normal; font-weight: 400; background-color: #ffffff;\" href=\"http:\/\/www.sanchez-vives.org\/\" target=\"_blank\" rel=\"noopener\">Sanchez-Vives Lab<\/a>\u00a0(M.V. Sanchez-Vives)<span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">, Barcelona, Spain.<\/span><\/li><li style=\"font-size: 15px;\"><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">Institute of Bioengineering of Catalonia (IBEC), Group:\u00a0<a style=\"font-size: 15px;\" href=\"http:\/\/www.ibecbarcelona.eu\/nanoprobes\" target=\"_blank\" rel=\"noopener\">Nanoprobes and nanoswitches<\/a>\u00a0(P. Gorostiza), Barcelona, Spain.<\/span><\/li><\/ul><div><b><u>Collaborations<\/u><\/b><\/div><ul style=\"font-size: 15px; font-style: normal; font-weight: 400;\"><li style=\"font-size: 15px; font-style: normal; font-weight: 400;\">Universit\u00e0 Sapienza, Department of Physiology and Pharmacology,\u00a0<a style=\"font-size: 15px;\" href=\"https:\/\/sites.google.com\/a\/uniroma1.it\/ferraina_lab\/\" target=\"_blank\" rel=\"noopener\">Ferraina Lab<\/a>\u00a0(S. Ferraina), Rome, Italy.<\/li><li style=\"font-size: 15px; font-style: normal; font-weight: 400;\">LENS,\u00a0<a style=\"font-size: 15px;\" href=\"http:\/\/lens.unifi.it\/bio\/\" target=\"_blank\" rel=\"noopener\">Biophysics Biophotonics Lab<\/a>\u00a0(F.S. Pavone), Florence, Italy<\/li><li style=\"font-size: 15px; font-style: normal; font-weight: 400;\"><span style=\"font-size: 15px;\">Forschungszentrum J\u00fclich, Institute of Neuroscience and Medicine, Computational and Systems Neuroscience (INM-6) &amp; Theoretical Neuroscience (IAS-6), Group:\u00a0<a style=\"font-size: 15px;\" href=\"http:\/\/www.fz-juelich.de\/inm\/inm-6\/EN\/Forschung\/Gruen\/artikel.html?nn=724694\" target=\"_blank\" rel=\"noopener\">Statistical Neuroscience<\/a>\u00a0(S. Gr\u00fcn),\u00a0<\/span>J\u00fclich, Germany.<\/li><li style=\"font-size: 15px; font-style: normal; font-weight: 400;\"><a href=\"https:\/\/www.athenarc.gr\/en\/athena-rc\/projects\/human-brain-project\">Athena Research Center<\/a>, Greece.<\/li><li style=\"font-size: 15px;\"><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">Heidelberg University, Heidelberg, Germany, Kirchhoff-Institut f\u00fcr Physik,\u00a0<a style=\"font-size: 15px;\" href=\"https:\/\/www.kip.uni-heidelberg.de\/vision\/\">Electronic Vision(s) &#8211; BrainScales<\/a>\u00a0(J. Schemmel),\u00a0<\/span><span style=\"font-size: 15px; font-style: normal; font-weight: 400;\">Heidelberg, Germany.<\/span><\/li><\/ul><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Human Brain Project (HBP) The Human Brain Project is a European-funded research initiative involving more than 100 institutions all over the continent.\u00a0The goal of the project is to unveil the secrets of the human brain and uncover the mechanisms responsible for cognitive processes, learning and consciousness.\u00a0The key-word for HBP is\u00a0multi-disciplinarity: HBP is not only a [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-234","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/apegate.roma1.infn.it\/index.php?rest_route=\/wp\/v2\/pages\/234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/apegate.roma1.infn.it\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/apegate.roma1.infn.it\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/apegate.roma1.infn.it\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/apegate.roma1.infn.it\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=234"}],"version-history":[{"count":110,"href":"https:\/\/apegate.roma1.infn.it\/index.php?rest_route=\/wp\/v2\/pages\/234\/revisions"}],"predecessor-version":[{"id":1578,"href":"https:\/\/apegate.roma1.infn.it\/index.php?rest_route=\/wp\/v2\/pages\/234\/revisions\/1578"}],"wp:attachment":[{"href":"https:\/\/apegate.roma1.infn.it\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}